Coinbase offer seamless integration of wallet and exchange features coinbase has rapidly increased its trading volume and provides decent liquidity on low spreads.
Kraken is a top European based exchange and offers a variety of fiat to bitcoin pairs. The exchange also has a smattering if popular crypto to crypto pairs including litecoin & ripple.
BitFinex offers three main functions - it is a bitcoin, litecoin and dashcoin to fiat exchange, a margin trading exchange and a liquidity provider.
Binance is a cryptocurrency exchange with a focus on the Chinese market and other Chinese coins. Currently, it supports English and Chinese users.